Responsibilities:

1. Construct the non-clinical pharmacology and toxicology research and development platform, including disease models, pharmacological mechanisms, PK/PD, etc.

2. Take on and guide the evaluation and research of pharmacological and toxicological for candidate and pipeline projects.

3. Write and review the registration application materials for related research and development projects.

4. Organize relevant pharmacological research work on the expansion of new indications of drugs.

5. Participate in the research and establishment of new projects and provide professional advice in the fields of drug efficacy, pharmacokinetics and toxicology.

Qualifications:

1. Ph.D. in Biomedicine, Medicine, 5+ years relevant experience, experience in tumor, immune and nervous system drug development is preferred.

2. 2+ years of management experience in biotechnology/pharmaceutical companies.

3. Good reading and writing skills both in Chinese and English.

Good at thinking, strong responsible, good coordination skills and good communication skills.

Responsibilities:

1. Design and formulate the clinical study protocols and related documents of new drug projects to promote the smooth progress of drug clinical research. Through internal discussions and communication with external medical experts and review experts, determine clinical strategies, write clinical plans and related materials.

2. Assist in the data management of clinical projects and the review of statistical analysis reports and summary reports, as well as related work on drug safety alert systems and medical monitoring.

3. Write clinical study protocols, investigator’s brochures, clinical study reports and other clinically relevant documents (including but not limited to meeting abstracts, posters and manuscripts, etc.)

4. Participate in the planning, initiation, implementation and management of clinical trials, assist in the review of clinical CRO documents, and assist in the analysis of clinical data.

5. Cooperate with the research team to ensure the correctness of data in clinical related documents and ensure that medical writing complies with ICH and related regulations.

6. Write and revise the clinical study related documents such as clinical protocol, informed consent, investigator manual and clinical summary report, and assist in the application of IND and NDA.

7. Retrieve, organize and analyze the medical information of similar drugs at home and abroad.

8. Participate in the establishment of the company's new drug research and development project, and provide project approval support from a medical perspective.

9. Participate in the investigation and survey of the indications, competitive environment and variety differentiation of the company's clinical drugs under research, and formulate corresponding clinical strategies.

Qualifications:

1. M.Sc. or Ph.D. in Clinical medicine, Biomedicine or other related majors.

2. 3+ years of clinical research work experience, experience in tumor, immune and nervous system drug development is preferred.

3. Familiar with the whole process of clinical research and regulations of clinical trial management regulations.

4. Excellent written and verbal communication skills.

5. Good reading and writing skills in Chinese and English.

Good at thinking, strong responsible, good coordination skills and good communication skills.

Responsibilities:

1. Take on the clinical project registration declaration and other related work, formulate project declaration plan, sort out, review, submit drug registration declaration materials, organize meetings.

2. Take on consultation on issues related to clinical registration, communicate and consult with the technical review department in a timely manner to formulate registration strategies for products.

3. Familiar with the procedures and requirements of clinical registration, track the progress of drug registration review and approval, and cooperate with the verification work of relevant departments, as well as the phased compliance review during the process of the project and before the application.

4. Take on the communication task of internal cross-departmental and relevant government departments for the registration projects, and provide pharmaceutical administrative support for the company's new project budget and proposal.

5. Timely summarize, classify, organize and archive various pharmaceutical regulations, documents and technical materials issued by the State Drug Administration.

6. Familiar with domestic drug-related laws and regulations, master the promulgation and policy trends of the latest regulatory affairs at home and abroad. Provide the company with professional knowledge of regulatory affairs, and analyze and report to the company's management team in a timely manner for major policy changes.

7. Responsible for the retrieval of drug and clinical project registration information, including sorting out registration information of competing products, etc.

Qualifications:

1. M.Sc. or Ph.D. in Pharmacy, Medicine, clinical or other related majors.

2. 3+ years of relevant experience in clinical registration declaration, familiar with national drug registration regulations, familiar with the drug registration declaration process and various links, and those with actual clinical work experience are preferred;

3. Possess good project management ability and problem-solving ability, good at analyzing problems and finding solutions;

4. Excellent written and verbal communication skills.

5. Good reading and writing skills in Chinese and English.

Good at thinking, love your job, good coordination skills and good communication skills.

Responsibilities:

1. Responsible for project outsourcing CRO screening, qualification assessment, contract drafting, signing, docking and liaison, etc. Follow up the progress of large molecule or small molecule drug evaluation, and be able to cooperate with biological, clinical, registration and other departments to follow up the drug IND application.

2. Responsible for writing or reviewing preclinical project research protocols, R&D plans, experimental reports and other materials.

3. Familiar with and master the in vivo, in vitro, pharmacodynamic, bioanalysis and pharmacotoxicology; cooperate with CRO to implement pharmacokinetic, pharmacodynamic, pharmacodynamic, toxicological assessment.

4. Summarize project information and literature, understand and collect the development trend of related products at home and abroad, and assist in the investigation and evaluation of new projects. Write project summary report and assist in patent application.

5. Complete other reasonable tasks arranged by the team.

Requirements:

1. M.Sc. or above, pharmacology, drug metabolism, toxicology and other related fields; 3-6 years of drug relevant work experience.

2. Ability to design and implement efficacy trials, evaluate efficacy and safety results, rich experience in ADME and PK experiments.

3. Experience in pharmacology and toxicology project management in CRO companies is preferred.

4. Possess solid basic knowledge of pharmacology and toxicology, understanding of national drug review requirements and drug management regulations, able to study pharmacology and toxicology related literature.

5. Proactive, highly responsible and motivated, strong problem-solving skills, strong project management experience, excellent professional ethics and teamwork spirit.

6. Proficient reading, writing and oral communication skills in English.

Responsibilities:

1. Responsible for the operation of the analytical laboratory and routine maintenance of instruments.

2. Skilled in the use of LCMS and HPLC, including the establishment, optimization, validation of analytical methods, compound purity and stability studies, analysis of biological samples and other work.

3. According to the company's R&D project needs, carry out the drugs' physical and chemical properties analysis, chiral analysis, and metabolic analysis.

4. Analyse, judge, summarize and record the experimental data.

5. Undertake the management of analytical projects independently, and report the results to the relevant responsible person.

6. Communicate with the project leader for the progress of the analytical project and solve the technical problems in the experiment.

7. Complete other reasonable tasks arranged by the team.

Requirements:

1. M.Sc. in analytical chemistry, pharmaceutical analysis, pharmacy, pharmaceutical engineering and other related fields, and Bachelor's degree with more than 2 years of work experience.

2. Comply the requirements of the analytical laboratory to complete analytical research and development independently.

3. Skilled in the establishment and validation, spectrum analysis of drug quality analysis methods.

4. Skilled in the use of LCMS, HPLC, GC and other chemical analysis instruments.

5. Proactive, enjoy studying intensively, good at communication, strong responsible, and good teamwork spirit.

Responsibilities:

1. Assist in the construction of animal mouse models of neurodegenerative diseases based on project requirements, and the establishment of corresponding technical platforms.

2. Assist in the screening of drug candidates using the above animal models.

3. Assist in the collection, organization and archiving of experimental data for team research projects.

4. Participate in the design and execution of the company's R&D projects.

5. Management of the small animal room.

Requirements:

1. M.Sc. in neurobiology, molecule biology or cell biology; excellent undergraduate candidates with work experience will also be considered.

2. Experience in animal pharmacodynamic model construction and animal pharmacodynamic trials.

3. Experience in western blot, qPCR, whole body perfusion of small animals, frozen sections and immunohistochemistry, primary cell culture is preferred (one of these is also acceptable).

4. Mastery of animal experimental skills, neurodegenerative disease model construction and behavioral testing is preferred.

5. Familiar with cell biology experimental methods: mammalian cell culture, cell freezing and storage, conventional plasmid transfection techniques.

6. Strong responsible, hard-working, willing to undertake responsibilities and challenges, good teamwork spirit.

Responsibilities:

1. Participate in the development and use of the company's computer-driven drug design platform.

2. Provide drug design support for small molecule drug projects with principles of computational chemistry and drug design.

3. Collaborate with medicinal chemists to design new compounds while working with R&D teams to advance drug development.

4. Use related technologies of AI and computational chemistry to research and develop small molecule drugs; provide technical support for drug design for new drug projects in various development stages.

5. Cooperate with cooperation partner, participate in collaborative small molecule drug development projects.

Requirements:

1. M.Sc. or Ph.D. in medicinal chemistry, computational chemistry or other related fields.

2. 0-5 years relevant experience in CADD.

3. Experience in virtual screening, small molecule docking, conformational analysis and free energy calculations is preferred.

4. Ability to perform protein and small molecule model construction, accomplish CADD task independently.

5. Familiar with the usage of some basic software of computational chemistry and drug design, e.g., Schrodinger package, MOE, DOCK.

6. Highly responsible and motivated, good coordination and collaboration skills; good team management skills.

7. Proficient reading, writing and oral communication skills in English.

Responsibilities: 

1. Accomplish bioinformatics data analysis task with bioinformatics and computational biology analysis methods and tools, supporting the company's small molecule drug R&D projects.

2. Identification and validation of biological targets, analysis of disease pathways and markers, and analysis of the relationship between genes, protein targets and diseases.

3. Mining and analysis of high-throughput omics data, integrating multiple omics and functional data to help and guide drug design and outcome prediction.

4. Develop and maintain an internal database based on a large amount of experimental data, and establish a data analysis platform to optimize the design process of drugs in pipeline.

5. Know the progress in the field of genomics and bioinformatics, collect and analyse clinical multi-omics data, support the pre-clinical and clinical drug development projects.

Requirements:

1. Ph.D. in relevant fields, including Bioinformatics, Computational Biology, Computer Science, Biology.

2. 2+ years relevant experience in Biotechnology/Pharmaceutical companies.

3. Familiar with Linux system, Python, Perl (at least proficient in one of them, Python experience is preferred).

4. Experience with relevant bioinformatic tools and databases (e.g., R software, NCBI, TCGA, GWAS, NGS).

5. Good reading and writing skills in both Chinese and English.

6. Good at thinking, love this job, have good communication and coordination skills.

Responsibilities:

1. Lead novel small drug R&D projects, cooperate with computational chemistry colleagues, undertake research/design task of medicinal chemistry to develop novel highly effective targeted drugs.

2. Design and implement drug discovery programs. Utilize SAR analysis and design philosophy of medicinal chemistry to optimize the leads’activity, selectivity and physicochemical properties, in vivo properties, etc.

3. Collaborate with biology team , design and synthesize new compounds to achieve key drug optimization goals.

4. Summarize project information and literature, understand and collect domestic and international trends of related products, and establish product advantages. Write project summary reports and relevant patents.

5. Proactively researching new chemical techniques to improve the efficiency of the drug discovery process.

Requirements:

1. Ph.D. in medicinal chemistry, organic chemistry or other related fields from a domestic or international university with 2-5 years of experience in new drug discovery.

2. Extensive experience in active compound design, efficiency optimization, compound selectivity, ADME and PK optimization.

3. Experience or knowledge of computational chemistry is preferred.

4. Extensive knowledge of organic synthesis reactions and good at following up on novel chemical reactions in the literature.

5. Proactive, highly responsible and motivated, strong problem-solving skills, strong project management experience, excellent professional ethics and teamwork spirit.

6. Good reading, writing and oral communication skills in English.

Responsibilities:

1. Responsible for the development and preparation of monoclonal and bispecific antibodies: familiar with molecular cloning and antibody expression purification, in vitro activity assay; familiar with a variety of antibody performance evaluation and improvement and other related work.

2. Carry out antibody research and development project. Conduct research on projects according to product requirements, be responsible for antibody development technical data collection, develop R&D plans and design reasonable development programs.

3. Manage and guide the staff in the group to complete antibody R&D work, responsible for the daily maintenance and management of antibody R&D laboratory to promote the smooth progress of antibody projects.

4. Summarized report on experimental results and R&D progress, and plan on the strategy of antibody project.

Requirements:

1. Ph.D. or above, majoring in immunology, biology, pharmacology or other related fields, with more than five years relevant experience in antibody drug discovery and development, with independent project experience, team management experience, and the ability or willingness to control project design, implementation and completion.

2. Ability to design and implement antibody efficacy experiments, safety assessment, characterization analysis, PK experiments, etc.

3. Skilled in molecular biology, antibody and recombinant protein expression and purification experience, cell culture and other experimental skills, biological functional analysis, animal experimental knowledge and experience, and pre-development of monoclonal antibody drugs.

4. Possess solid basic knowledge and be able to study and master the literature related to antibody drugs.

5. Proactive, highly responsible and motivated, strong problem-solving skills, strong project management experience, excellent professional ethics and teamwork spirit.

6. Proficient reading, writing and oral communication skills in English.